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KMID : 0191120080230030533
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Journal of Korean Medical Science
2008 Volume.23 No. 3 p.533 ~ p.536
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A Case of a Patient with Both Chorea and Restless Legs Syndrome
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Shin Yoon-Kyung
Jeong Jong-Hyun
Hong Seung-Chul
Han Jin-Hee
Lee Sung-Pil
Ihn Yon-Kwon
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Abstract
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The patient was a 44-yr-old man with end-stage renal disease who had developed chorea as a result of hypoglycemic injury to the basal ganglia and thalamus and who was subsequently diagnosed with depression and restless legs syndrome (RLS). For proper management, the presence of a complex medical condition including two contrasting diseases, chorea and RLS, had to be considered. Tramadol improved the pain and dysesthetic restlessness in his feet and legs, and this was gradually followed by improvements in his depressed mood, insomnia, lethargy, and feelings of hopelessness. This case suggests that the dopaminergic system participates intricately with the opioid, serotoninergic, and noradrenergic systems in the pathophysiology of RLS and pain and indirectly of depression and insomnia.
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KEYWORD
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Restless Legs Syndrome, Chorea, Sleep Initiation and Maintenance Disorde, Depression, Tramadol
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